God has abandoned Heaven. It's 1985: the Reagans are in the White House and Death swings the scythe of AIDS. In Manhattan, Prior Walter tells Louis, his lover of four years, he's ill; Louis leaves but as disease and loneliness ravage Prior, guilt invades Louis. Joe Pitt, a Mormon Republican attorney, is pushed by right-wing fixer Roy Cohn toward a job at the Justice Department. Pitt and Cohn are closeted: Pitt, out of shame and religious turmoil; Cohn, to preserve his power and access. Pitt's wife Harper is strung out on Valium, aching to escape a sexless marriage. An angel invites Prior to be a prophet in death.
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